Player Draft
| Name | State | School | Class | Pos. | Year | Round | Team |
| AJ Shaver | FL | South Lake | 2020 | OF | 2023 | 17 | Phillies |
| Matthew Shaw | MA | Worcester Academy | 2020 | SS | 2023 | 1 | Cubs |
| Sam Shaw | BC | Lambrick Park | 2023 | SS | 2023 | 9 | Blue Jays |
| Evan Shawver | OH | Amherst Steele | 2018 | LHP | 2021 | 7 | Colorado Rockies |
| Ben Sheckler | MI | Cornerstone | 2013 | LHP | 2016 | 8 | Padres |
| George Emmet Sheehan | CT | Salisbury School | 2018 | RHP | 2021 | 6 | Los Angeles Dodgers |
| Austin Shields | ON | St. Mary's Catholic Secondary School | 2016 | RHP | 2016 | 33 | Pirates |
| Luke Shilling | MI | Notre Dame Prep | 2015 | RHP | 2015 | 20 | Rangers |
| Wooyeoul Shin | JUCO | South Korea | 2020 | 2B | 2023 | 16 | Rays |
| Jaxon Shirley | IN | Lapel | 2016 | 3B | 2016 | 34 | White Sox |
| Luke Shliger | NY | Trinity Pawling | 2020 | C | 2023 | 6 | Giants |
| Adam Shoemaker | ON | St. Benedict | 2021 | LHP | 2021 | 11 | Atlanta Braves |
| Avery Short | IN | Southport | 2019 | LHP | 2019 | 12 | Diamondbacks |
| Zack Showalter | FL | Wesley Chapel | 2022 | RHP | 2022 | 11 | Orioles |
| Darren Shred | ON | St. Roch Catholic | 2015 | C | 2015 | 22 | Reds |
| Dalton Shuffield | TX | Johnson | 2017 | SS | 2022 | 10 | Twins |
| Nick Shumpert | CO | Highlands Ranch | 2015 | SS | 2016 | 28 | Braves |
| Mike Siani | PA | William Penn Charter | 2018 | OF | 2018 | 4 | Reds |
| Sam Siani | PA | William Penn Charter | 2019 | OF | 2019 | Comp. Balance A | Pirates |
| TJ Sikkema | IA | Central Dewitt | 2016 | LHP | 2019 | 38th Overall Pi | Yankees |
| Easton Sikorski | MI | De La Salle Collegiate | 2018 | RHP | 2022 | 17 | Reds |
| William Silva | FL | Miami Coral Park | 2019 | RHP | 2022 | 15 | Braves |
| Eric Silva | CA | JSerra | 2021 | RHP | 2021 | 4 | SF |
| Anthony Silvas | CA | Moreno Valley | 2021 | RHP | 2023 | 16 | Twins |
| Kevin Sim | CA | Torrey Pines | 2020 | 3B | 2023 | 5 | Diamondbacks |
| Karson Simas | CA | Clovis West | 2019 | SS | 2019 | 26 | Red Sox |
| Cameron Simmons | PA | Spring-Ford | 2015 | OF | 2019 | 20 | White Sox |
| Dylan Simmons | FL | Trinity Christian Academy | 2019 | RHP | 2023 | 15 | Reds |
| Kendall Logan Simmons | GA | Tattnall Square Academy | 2018 | SS | 0 | 6 | P |
| Liam Simon | NJ | Freehold Township | 2019 | RHP | 2022 | 5 | Giants |
| Benjamin Simon | NJ | Hightstown | 2020 | RHP | 2023 | 13 | Mets |
| Anthony Simonelli | VA | Millbrook | 2017 | RHP | 2021 | 16 | Royals |
| Jared Simpson | IA | Clinton | 2018 | LHP | 2023 | 8 | Nationals |
| Chandler Simpson | GA | St. Pius X Catholic | 2019 | 2B | 2022 | CBB | Rays |
| Will Simpson | WA | Skyline | 2019 | 1B | 2023 | 15 | Athletics |
| Demetrius Sims | MI | Ann Arbor Huron | 2013 | SS | 2017 | 14 | Marlins |
| Jacob Sims | ON | Bishop Mac | 2015 | C | 2018 | 31 | San Diego Padres |
| Landon Sims | GA | South Forsyth | 2019 | RHP | 2022 | CBA | Diamondbacks |
| Brady Singer | FL | Eustis | 2015 | RHP | 2015 | 2 | Blue Jays |
| Michael Sirota | CT | The Gunnery | 2021 | OF | 2021 | 16 | Los Angeles Dodgers |
| Brandyn Sittinger | OH | Keystone | 2012 | RHP | 2016 | 17 | Tigers |
| Kyle Skeels | PA | Neshaminy | 2015 | C | 2019 | 36 | Cardinals |
| Ethan Skender | IL | Metamora | 2015 | SS | 2016 | 28 | Padres |
| Paul Skenes | CA | El Toro | 2020 | RHP | 2023 | 1 | PIT |
| Carson Skipper | AL | Hewitt Trussville | 2018 | LHP | 2022 | 11 | Rockies |
| Evan Skoug | IL | Libertyville | 2014 | C | 2017 | 7 | White Sox |
| Johnny Slater | MI | Southfield-Lathrup | 2013 | OF | 2017 | 28 | Mariners |
| Jake Slaughter | LA | Ouachita Christian | 2016 | SS | 2018 | 18th | Cubs |
| Ryan Sloniger | PA | Punxsutawney Area | 2015 | C | 2019 | 38 | Blue Jays |
| Jackson Smeltz | IN | McCutcheon | 2018 | LHP | 2022 | 10 | Padres |
| Matthew Smith | PA | Seneca Valley | 2012 | RHP | 2016 | 34 | Brewers |
| Angelo Smith | IL | Richards | 2017 | LHP | 2017 | 40 | White Sox |
| Kevin Smith | NY | Columbia | 2014 | - | 2017 | 4 | Blue Jays |
| Austin Smith | FL | Park Vista | 2015 | RHP | 2015 | 2 | Padres |
| Josh Smith | LA | Catholic (BR) | 2016 | SS | 2019 | 2nd | Yankees |
| Marcus Smith | MO | Pembroke Hill | 2019 | OF | 2019 | 3 | A's |
| Jake Smith | NC | Chapel Hill | 2018 | RHP | 2018 | 21 | Philadelphia Phillies |
| Kyle Smith | NC | New Hanover | 2019 | C | 2019 | 36 | Arizona Diamondbacks |
| LaRon Smith | AB | Okotoks Dawgs Academy | 2018 | SS | 2018 | 25 | Minnesota Twins |
| Cade Smith | MS | DeSoto Central | 2020 | RHP | 2023 | 6 | Yankees |
| D'Andre Smith | CA | San Dimas | 2020 | SS | 2022 | 5 | Mets |
| Kelvin Smith | GA | Redan | 2018 | SS | 2018 | 20th | Tigers |
| David Smith | PA | Perkiomen School | 2019 | 2B | 2023 | 14 | Tigers |
| Sincere Smith | NC | East Bladen | 2018 | SS | 2018 | 32 | New York Yankees |
| Brady Smith | TN | Grainger | 2023 | RHP | 2023 | 3 | Dodgers |
| Aidan Smith | TX | Lovejoy | 2023 | OF | 2023 | 4 | Mariners |
| Cade Smitherman | TX | Lovejoy | 2019 | OF | 2017 | 16 | Twins |
| Matt Smoral | OH | Solon | 2012 | LHP | 2012 | 1 | Blue Jays |
| Ryan Snell | TX | Hardin | 2018 | RHP | 2023 | 7 | Nationals |
| Robby Snelling | NV | McQueen | 2022 | LHP | 2022 | CBA | Padres |
| Hayden Snelsire | MD | Stephen Decatur | 2019 | RHP | 2023 | 17 | Rays |
| DJ Snelton | IL | Lakes | 2010 | LHP | 2013 | 9 | Giants |
| Tyler Soderstrom | CA | Turlock | 2020 | C | 2020 | 1 | Oakland |
| Nick Solak | IL | Naperville North | 2013 | SS | 2016 | 2 | Yankees |
| Noah Soles | NC | Ledford | 2019 | OF | 2019 | 19 | Arizona Diamondbacks |
| Anthony Solometo | NJ | Bishop Eustace | 2021 | LHP | 2021 | 2 Pick 37 | Pittsburgh Pirates |
| Jared Solomon | PA | Millville | 2015 | RHP | 2017 | 11 | Reds |
| Tommy Sommer | IN | Carmel | 2017 | LHP | 2021 | 10 | White Sox |
| Jake Sommers | WI | Hortonville | 2015 | RHP | 2019 | 10 | Cardinals |
| Drew Sommers | CA | Carlsbad | 2019 | LHP | 2022 | 11 | Rays |
| Logan Soole | CO | Monarch | 2015 | LHP | 2015 | 23 | Diamondbacks |
| Zack Soria | IL | St. Rita | 2012 | C | 2017 | 18 | Braves |
| Gustavo Sosa | NY | Tottenville | 2019 | C | 2022 | 10 | Phillies |
| Charlee Soto | FL | Reborn Christian Academy | 2023 | RHP | 2023 | 1-A | Twins |
| Jared Southard | TX | Rouse | 2019 | RHP | 2022 | 12 | Angels |
| Logan Sowers | IN | McCutcheon | 2014 | OF | 2018 | 28 | White Sox |
| Garrett Spain | TN | Clarksville | 2018 | OF | 2021 | 15 | Blue Jays |
| Chad Spanberger | IL | Granite City | 2014 | C | 2017 | 6 | Rockies |
| Zach Spears | IN | Mt. Vernon | 2015 | LHP | 2018 | 8 | Pirates |
| Tommy Specht | IA | Wahlert Catholic | 2022 | OF | 2022 | 6 | Rangers |
| Joey Spence | WI | West Bend East | 2021 | C | 2021 | 18 | Arizona Diamondbacks |
| Ryan Spikes | GA | Parkview | 2021 | SS | 2021 | 3rd | Tampa Bay Rays |
| Bren Spillane | IL | Wheeling | 2015 | 1B | 2018 | 3 | Reds |
| Ben Spitznagel | OH | Colerain | 2013 | OF | 2017 | 27 | Athletics |
| Blair Springfield | IL | Decatur MacArthur | 2009 | SS | 2009 | 7 | Cubs |
| Jordan Sprinkle | CA | Palm Desert | 2019 | SS | 2022 | 4 | White Sox |
| Brandon Sproat | FL | Pace | 2019 | RHP | 2022 | 3 | Mets |
| Fitz Stadler | IL | Glenbrook South | 2015 | RHP | 2018 | 18 | Blue Jays |
| Deon Stafford Jr. | PA | Lower Dauphin | 2014 | C | 2017 | 5 | Pirates |
| Samuel Stafura | NY | Walter Panas | 2023 | SS | 2023 | 2 | Cincinnati Reds |