| Name | State | School | Class | Pos. | Year | Round | Team |
| Juan Carlos Abreu | FL | Winter Springs | 2016 | OF | 2016 | 23 | Red Sox |
| Cory Acton | FL | American Heritage | 2018 | 2B | 2022 | 9 | Braves |
| Eric Adler | FL | Rockledge | 2019 | RHP | 2022 | 6 | White Sox |
| Mason Albright | FL | IMG Academy | 2021 | LHP | 2021 | 12 | Los Angeles Angels |
| Blaze Alexander | FL | IMG Academy | 2018 | SS | 2018 | 11th | Arizona Diamondbacks |
| Michael Alfonso | FL | Key West | 2021 | SS | 2021 | 17 | Texas Rangers |
| Matthew Allan | FL | Seminole | 2019 | RHP | 2019 | 3rd | New York Mets |
| Logan Allen | FL | IMG Academy | 2015 | LHP | 2015 | 8 | Red Sox |
| Logan Allen | FL | University | 2017 | LHP | 2017 | 16 | Orioles |
| Jay Allen | FL | John Carroll Catholic | 2021 | OF | 2021 | 1C | Cincinnati Reds |
| Nelson Alvarez | FL | Braddock | 2016 | RHP | 2016 | 27 | Indians |
| Mike Amditis | FL | Boca Raton | 2016 | C | 2016 | 37 | Indians |
| Edmond Americaan | FL | Trinity Christian Academy | 2016 | OF | 2016 | 28 | Diamondbacks |
| Roman Anthony | FL | Stoneman Douglas | 2022 | OF | 2022 | 2C | Red Sox |
| Oraj Anu | FL | TNXL Academy | 2017 | OF | 2017 | 28 | Red Sox |
| Edwin Arroyo | FL | Central Pointe Christian | 2021 | SS | 2021 | 2 | Seattle Mariners |
| Andrew Baker | FL | Ridge Community | 2016 | LHP | 2016 | 36 | Indians |
| Thomas Balboni | FL | St John Neumann | 2019 | RHP | 2022 | 15 | Padres |
| Hunter Barco | FL | Bolles | 2019 | LHP | 2022 | 2 | Pirates |
| Brandon Barriera | FL | American Heritage Plantation | 2022 | LHP | 2022 | 1 | Blue Jays |
| William Bartlett | FL | IMG Academy | 2019 | C | 2019 | 9th | Cleveland Indians |
| Justin Bench | FL | Calvary Christian | 2018 | SS | 2022 | 17 | Giants |
| Austin Bergner | FL | Windermere Prep | 2016 | RHP | 2016 | 38 | Red Sox |
| Bo Bichette | FL | Lakewood | 2016 | 3B | 2016 | 2 | Blue Jays |
| JJ Bleday | FL | Mosley | 2016 | OF | 2016 | 39 | Padres |
| Bo Bonds | FL | Suwannee | 2019 | RHP | 2022 | 13 | Blue Jays |
| Julian Bosnic | FL | Berkely Prep | 2018 | LHP | 2022 | 14 | Pirates |
| Hunter Bowling | FL | American Heritage | 2015 | LHP | 2015 | 39 | Giants |
| Cody Brickhouse | FL | Sarasota | 2015 | 3B | 2015 | 15 | Giants |
| Garrison Bryant | FL | Clearwater | 2016 | RHP | 2016 | 36 | Mets |
| Jordan Butler | FL | Alonso | 2017 | LHP | 2017 | 34 | Yankees |
| Andrew Cabezas | FL | Coral Gables Senior | 2015 | RHP | 2015 | 34 | Indians |
| Christian Cairo | FL | Calvary Christian | 2019 | SS | 2019 | 4th | Cleveland Indians |
| Tyler Callihan | FL | Providence | 2019 | SS | 2019 | 3rd | Cincinnati Reds |
| Irving Carter | FL | Calvary Christian Academy | 2021 | RHP | 2021 | 5 | Toronto Blue Jays |
| Triston Casas | FL | American Heritage | 2018 | 1B | 2018 | 1st | Boston Red Sox |
| Cash Case | FL | The First Academy | 2017 | SS | 2017 | 4 | Reds |
| Slade Cecconi | FL | Trinity Prep | 2018 | RHP | 2018 | 38th | Baltimore Orioles |
| Joseph Charles | FL | TNXL Academy | 2019 | RHP | 2019 | 25th | New York Mets |
| Chris Chatfield | FL | Spoto | 2015 | OF | 2015 | 23 | Padres |
| Evan Chrest | FL | Wharton | 2022 | RHP | 2022 | 17 | Marlins |
| Anthony Churlin | FL | Island Coast | 2016 | OF | 2016 | 16 | Athletics |
| Jurrangelo Cijntje | FL | Champagnat Catholic | 2022 | RHP | 2022 | 18 | Brewers |
| Logan Clayton | FL | New Smyrna Beach | 2018 | RHP | 2022 | 17 | Diamondbacks |
| Justin Cohen | FL | Riverview | 2015 | C | 2015 | 6 | Marlins |
| Griffin Conine | FL | Pine Crest | 2015 | OF | 2015 | 31 | Marlins |
| Justin Connell | FL | American Heritage | 2017 | SS | 2017 | 11 | Nationals |
| Nick Conti | FL | Dr Phillips | 2015 | 2B | 2015 | 40 | Mets |
| Gavin Conticello | FL | Stoneman Douglas | 2021 | SS | 2021 | 8 | Arizona Diamondbacks |
| Matthew Corlew | FL | North Broward Prep | 2019 | OF | 2019 | 23rd | Los Angeles Angels |
| Carlos Cortes | FL | Lake Howell | 2016 | OF | 2016 | 20 | Mets |
| Paul Coumoulos | FL | College of Central Florida | 2017 | OF | 2017 | 40 | Phillies |
| Logan Crouse | FL | Bloomingdale | 2015 | RHP | 2015 | 30 | Dodgers |
| Luis Curbelo | FL | Cocoa | 2016 | SS | 2016 | 6 | White Sox |
| Nander De Sedas | FL | Montverde Academy | 2018 | SS | 2018 | 29th | Milwaukee Brewers |
| Ryan Dease | FL | TNXL Academy | 2017 | RHP | 2017 | 4 | Rangers |
| Dylan DeLucia | FL | New Smyrna Beach | 2019 | RHP | 2022 | 6 | Guardians |
| Mason Denaburg | FL | Merritt Island | 2018 | RHP | 2018 | 1st | Washington Nationals |
| Nick Derr | FL | Sarasota | 2016 | SS | 2016 | 33 | Reds |
| Michael Dominguez | FL | Jefferson | 2019 | RHP | 2019 | 15th | Toronto Blue Jays |
| Carson Dorsey | FL | J.R. Arnold | 2021 | LHP | 2022 | 17 | Rangers |
| Terence Doston | FL | Hillsborough | 2019 | OF | 2019 | 22nd | Milwaukee Brewers |
| Jeter Downs | FL | Pace | 2017 | SS | 2017 | 1 | Reds |
| Shane Drohan | FL | Cardinal Newman | 2017 | LHP | 2017 | 23 | Phillies |
| Juan Javier Echevarria | FL | Osceola | 2015 | RHP | 2015 | 21 | Orioles |
| Jake Eder | FL | Calvary Christian | 2017 | LHP | 2017 | 34 | Mets |
| Zachary Ehrhard | FL | Wharton | 2021 | SS | 2021 | 13 | Boston Red Sox |
| Tim Elko | FL | Hillsborough | 2017 | 3B | 2022 | 10 | White Sox |
| Kole Enright | FL | West Orange | 2016 | 3B | 2016 | 3 | Rangers |
| Dylan Eskew | FL | Sickles | 2019 | RHP | 2019 | 24th | Arizona Diamondbacks |
| Tyler Esplin | FL | IMG Academy | 2017 | OF | 2017 | 7 | Red Sox |
| Ty Evans | FL | Lakeland Christian | 2021 | OF | 2021 | 20 | Atlanta Braves |
| Andrew Eyster | FL | Forest | 2017 | OF | 2017 | 27 | Diamondbacks |
| Judson Fabian | FL | Trinity Catholic | 2018 | OF | 2022 | CBB | Orioles |
| Cade Fergus | FL | St Thomas Aquinas | 2018 | - | 2022 | 13 | Phillies |
| Jackson Ferris | FL | IMG Academy | 2022 | LHP | 2022 | 2 | Cubs |
| JC Flowers | FL | Trinity Christian Academy | 2016 | RHP | 2016 | 18 | Reds |
| Walter Ford | FL | Pace | 2022 | RHP | 2022 | CBB | Mariners |
| Gentry Fortuno | FL | Flanagan | 2015 | RHP | 2015 | 18 | Brewers |
| Jake Fox | FL | Lakeland Christian | 2021 | SS | 2021 | 3 | Cleveland Indians |
| Harrison Francis | FL | Chiles | 2017 | RHP | 2017 | 4 | Diamondbacks |
| Austin Franklin | FL | Paxton | 2016 | RHP | 2016 | 3 | Rays |
| Alex Freeland | FL | Mariner | 2020 | SS | 2022 | 3 | Dodgers |
| Branden Fryman | FL | Tate | 2016 | SS | 2016 | 37 | Rangers |
| Nelson Galindez | FL | Haines City | 2017 | LHP | 2017 | 22 | Nationals |
| Jose Garcia | FL | Doral Academy Charter | 2017 | C | 2017 | 38 | Red Sox |
| Jake Garland | FL | Jupiter | 2019 | RHP | 2022 | 17 | Athletics |
| Joe Genord | FL | Park Vista Community | 2015 | 1B | 2015 | 19 | Dodgers |
| Raymond Gil | FL | Gulliver Prep | 2017 | 3B | 2017 | 37 | Athletics |
| Nick Gordon | FL | Olympia | 2014 | SS | 2014 | 1 | Twins |
| Drew Gray | FL | IMG Academy | 2021 | OF | 2021 | 3 | Chicago Cubs |
| Elijah Green | FL | IMG Academy | 2022 | OF | 2022 | 1 | Nationals |
| Riley Greene | FL | Hagerty | 2019 | OF | 2019 | 1st | Detroit Tigers |
| Foster Griffin | FL | The First Academy | 2014 | LHP | 2014 | 1 | Royals |
| Vaughn Grissom | FL | Hagerty | 2019 | SS | 2019 | 11th | Atlanta Braves |
| Luis Guerrero | FL | Home School | 2019 | RHP | 2021 | 17 | Red Sox |
| Shawn Guilliams | FL | Villages Charter | 2020 | RHP | 2021 | 11 | Cincinnati Reds |
| Dalton Guthrie | FL | Venice | 2014 | SS | 2014 | 40 | Twins |
| Tayden Hall | FL | Steinbrenner | 2021 | C | 2022 | 9 | Brewers |
| Ryan Harbin | FL | Bartow | 2019 | OF | 2019 | 17th | Pittsburgh Pirates |
